Sherain Harricharan

Sherain Harricharan, PhD
McMaster University

Sherain Harricharan is currently pursuing a Postdoctoral Fellowship in the Department of Psychiatry and Behavioural Neurosciences under the supervision of Dr. Margaret McKinnon. She received her undergraduate degree in Biology and Medical Sciences at Western University, and then went on to complete her doctoral degree in Neuroscience at Western University with Dr. Ruth Lanius. Sherain’s research focuses on post-traumatic stress disorder, employing various neuroimaging approaches to study altered neural circuitry patterns among traumatized individuals. Her research interests include studying how sensory processing pathways in the brain are altered as a function of trauma and dissociation, emphasizing their impact on the performance of higher-order cognitive functions, including emotion regulation, social cognition, and attentional processing. Sherain is dedicated to identifying neural correlates that can aid in the development of clinically-oriented sensorimotor treatments for PTSD.

Publications:

Harricharan, S., Rabellino, D., Frewen, P.A., Densmore, M., Théberge, J., Mckinnon, M.C., Schore, A.N., Lanius, R.A. (2016). fMRI functional connectivity of the periaqueductal gray in PTSD and its dissociative subtype. Brain and Behavior, 6: e00579, 1-16.

Harricharan, S., Nicholson, A. A., Densmore, M., Théberge, J., McKinnon, M. C., Neufeld, R. W., & Lanius, R. A. (2017). Sensory overload and imbalance: Resting-state vestibular connectivity in PTSD and its dissociative subtype. Neuropsychologia, 106: 169-178.

Harricharan, S., McKinnon, M.C., Tursich, M., Densmore, M., Frewen, P., Théberge, J., van der Kolk, B., Lanius, R. A. (2019). A pilot study examining overlapping frontoparietal networks in response to oculomotion and traumatic autobiographical memory retrieval: Implications for eye movement desensitization and reprocessing. European Journal of Psychotraumatology. 10(1), 1586265.

Harricharan, S., Nicholson, A.A., Thome, J., Densmore, M., McKinnon, M.C., Théberge, J., Frewen, P.A., Neufeld, R.W.J., Lanius, R.A. (2020). PTSD and its dissociative subtype through the lens of the insula: Anterior and posterior insula resting-state functional connectivity and its predictive validity using machine learning. Psychophysiology, 57(1), e13472.

Lanius, R. A., Rabellino, D., Boyd, J. E., Harricharan, S., Frewen, P. A., & McKinnon, M. C. (2017). The innate alarm system in PTSD: conscious and subconscious processing of threat. Current Opinion in Psychology, 14, 109-115.

Nicholson, A. A., Friston, K. J., Zeidman, P., Harricharan, S., McKinnon, M. C., Densmore, M., Neufeld, R.W., Théberge, J., Corrigan, F., Jetly, R., Spiegel, D. (2017). Dynamic causal modeling in PTSD and its dissociative subtype: Bottom–up versus top–down processing within fear and emotion regulation circuitry. Human Brain Mapping, 38, 5551-5561.

Nicholson, A. A., Harricharan, S., Densmore, M., Neufeld, R. W., Ros, T., McKinnon, M. C., … & Lanius, R. A. (2020). Classifying Heterogeneous Presentations of PTSD via the Default Mode, Central Executive, and Salience Networks with Machine Learning. NeuroImage: Clinical, 102262. In press.

Rabellino, D., Burin, D., Harricharan, S., Lloyd, C., Frewen, P. A., McKinnon, M. C., & Lanius, R. A. (2018). Altered sense of body ownership and agency in posttraumatic stress disorder and its dissociative subtype: a rubber hand illusion study. Frontiers in human neuroscience, 12, 163.

Rabellino, D., Densmore, M., Harricharan, S., Théberge, J., McKinnon, M. C., & Lanius, R. A. (2017). Resting-state functional connectivity of the bed nucleus of the stria terminalis in post-traumatic stress disorder and its dissociative subtype. Human Brain Mapping, 39(3), 1367-1379.

Olivé, I., Densmore, M., Harricharan, S., Théberge, J., McKinnon, M. C., & Lanius, R. (2018). Superior colliculus resting state networks in post-traumatic stress disorder and its dissociative subtype. Human Brain Mapping, 39(1), 563-574.

Terpou, B. A., Harricharan, S., McKinnon, M. C., Frewen, P., Jetly, R., & Lanius, R. A. (2019). The effects of trauma on brain and body: A unifying role for the midbrain periaqueductal gray. Journal of neuroscience research, 97(9), 1110-1140.