Trauma Publications

+ Funded/resourced by HRI
* Conducted at Homewood
Underlined Research Trainees

2019

+*An open-label feasibility trial examining the effectiveness of a cognitive training program, Goal Management Training, in individuals with posttraumatic stress disorder (accepted manuscript)
Boyd, J.E. · O’Connor, C. · Protopopescu, A. · Jetly, R. · Rhind, S. · Lanius, R.A. · McKinnon, M.C.

+Assessing Post-Traumatic Tonic Immobility Responses: The Scale for Tonic Immobility Occurring Post-Trauma
Lloyd C.S. · Lanius, R.A. · Brown, M.F. · Neufeld, R.J. · Frewen, P.A. · McKinnon, M.C.

Evidence-based treatments for major depressive disorder (in press)
Milanovic, M. · McNeely, H. · Qureshi, A. · McKinnon, M.C. · Holhausen, K.

+The innate alarm system: A translational approach
Rabellino, D· Boyd, J. · McKinnon, M.C. · Lanius R.A.

The innate alarm system and subliminal threat presentation in PTSD: Neuroimaging of the midbrain and cerebellum
Terpou, B.A. · Densmore, M. · Thome, J. · Frewen, P.A. · McKinnon, M.C.  Lanius, R.A.

Overlapping frontoparietal networks in response to oculomotion and traumatic autobiographical memory revival: Implications for eye movement desensitization and reprocessing (in press)
Harricharan, S. · McKinnon, M.C. · Tursich, M. · Densmore, M. · Frewen, P.A. · Theberge, J. · van der Kolk, B. · Lanius, R.A.

+*The relation between adverse childhood experiences and moral injury in the Canadian Armed Forces
Battaglia, A. · Protopopescu, A. · Boyd, J. · Lloyd, C. · Jetly, R. · O’Connor, C. · Hood, H.K. · Nazarov, A. · Rhind, S. · Lanius, R.A. · McKinnon, M.C.

2018

+A review of the neurobiological basis of trauma-related dissociation and its relation to cannabinoid-and opiod-mediated stress response: A transdiagnostic, translational approach 
Lanius, R.A. ·  
Boyd, J.E. · McKinnon, M.C. · Nicholson, A.A. · Frewen, P.A. · Vermetten, E. · Jetly, R. · Spiegel, D.

+Altered sense of body ownership and agency in posttraumatic stress disorder and its dissociative subtype: A rubber hand illusion study
Rabellino, D. · Burin, D. · Harricharan, S. · Lloyd, C. · Frewen, P.A. · McKinnon, M.C. · Lanius, R.A.

+The cerebellum after trauma: Resting-state functional connectivity of the cerebellum in posttraumatic stress disorder and its dissociative subtype
Rabellino, D. · Densmore, M. · Théberge, J. · McKinnon, M.C. · Lanius, R.A.

The dissociative subtype of PTSD: An update of the literature
Schaivone, F.L. · Frewen, P.A. · McKinnon, M.C. · Lanius R.A.

+*Dissociative symptoms mediate the relation between PTSD symptoms and functional impairment in a sample of military members, veterans, and first responders with PTSD  
Boyd, J.E. · Protopopescu, A. · O’Connor, C. · Neufeld, R.W.J. · Jetley, R. · Hood, H.K. · Lanius, R.A. · McKinnon, M.C.

Effects of a 12-week running program in youth and adults with complex mood disorders
Keating, L.E. · Becker, S. · McCabe, K. · Whattam, J. · Garrick, L. · Sassi, R. · Frey, B.N. · McKinnon, M.C.

Excessive reassurance-seeking and cognitive confidence in obsessive-compulsive disorder
Orr, E. · McCabe, R. · McKinnon, M.C. · Rectorm N.A. · Ornstein, T.J.

+Intrinsic connectivity network dynamics in PTSD during downregulation of the amygdala using real-time fMRI neurofeedback
Nicholson, A.A. · Rabellino, D. · Densmore, M. · Frewen, P.A. · Paret, C. · Kluetsch, R. · Schmal, C. · Théberge, J. · Ros, T. · Neufeld, R.W.J. · McKinnon, M.C· Reiss, J. · Jetly, R. · Lanius, R.A. 

+Machine learning multivariate pattern and analysis predicts classification of posttraumatic stress disorder and its dissociative subtype: A multimodal neuroimaging approach
Nicholson, A.A. ·  Densmore, D. ·  McKinnon, M.C. ·  Neufeld, R.W.J. · Frewen, P.A. · Théberge, J. · Jetly, R. · Richardson, D. · Lanius, R.A.

+Mindfulness-based treatments for posttraumatic stress disorder: A review of the treatment literature and neurobiological evidence
Boyd, J.E. · Lanius, R.A. · McKinnon, M.C.

+Neural and behavioural correlates of autobiographical memory retrieval in patients with major depressive disorder and a history of trauma exposure
Parlar, M. · Densmore, M. · Hall, G. · Lanius, R.A. · McKinnon, M.C. 

Psychotic-like symptoms and the temporal lobe in trauma-related disorders: Diagnosis, treatment and assessment of malingering
Schiavone, F.L. · McKinnon, M.C. · Lanius R.A.

+Resting-state functional connectivity of the bed nucleus of the stria terminalis in post-traumatic stress disorder and its dissociative subtype
Rabellino, D.
 · Densmore, M. · Harricharan, S. · Théberge, J. · McKinnon, M.C. · Lanius, R.A.

Resting-state pulvinar-posterior parietal decoupling in PTSD and its dissociative subtype
Terpou, B.A. · Densmore, M. · Theberge, J. · Frewan, P.A. · McKinnon, M.C. · Lanius, R.A.

Smaller hippocampal volume in posttraumtic stress disorder: A multi-site ENIGMA-PGC study: Subcortial volumetry results from posttraumatic stress disorder consortia.
Logue, M.W. · van Rooij, S.J.H. · Dennis, E.L. · Davis, S.L. · Hayes, J.P. · Stevens, J. S. · Densmore, M. · Haswell, C.C. · Ipser, J. · Koch, S.B. · Korgaonkar, M. · Lebois, L.A.M. · Peverill, M. · Baker, J.T. · Boedhoe, P.S.M. · Frijling, J.L. · Gruber, S.A. · Harpaz-Rotem, I. · Jahanshad, N. · Koopowitz, S. · Levy, I. · Nawijn, L. · O’Connor, L · Olff, M. · Salat, D.H. · Sheridan, M.A. · Speilberg, J.M. · van Zuiden, M. · Winternitz, S.R. · Wolff, J.D. · Wolf, E.J. · Wang, X. · Wrocklage, K. · Abdallah, C.G. · Bryant, R.A. · Geuze, E. · Jovanovic, T. · Kaufman, M. · King, Ap. · Krystal, J.H. · Lagopoulos, J. · Lanius, R.A. · Liberzon, I. · McGlinchey, R.E. · McLaughlin, K.A. · Milberg, W.P. · Miller, M.W. · Ressler, K.J. · Stein, D.J. · Thomaes, K. · Thompson, P.M. · Morey, R.A.

Superior colliculus connectivity in post-traumatic stress disorder and its dissociative subtype
Olive, I. · Densmore, M. · Harricharan, S. · Théberge, J. · McKinnon, M.C. · Lanius, R.A.

Superior colliculus resting state networks in post-traumatic stress disorder and its dissociative subtype
Olivé, I. · Densmore, M. · Harricharan, S. · Théberge, J. · McKinnon, M.C. · Lanius, R.A.

2017

Abnormal self-schema in semantic memory in major depressive disorder: Evidence from event-related brain potentials
Kiang, M. · Farzan, F. ·  Blumberger, D.F. · Kutas, M. ·  McKinnon, M.C. ·  Kansal, V. ·  Rajji, T.K. ·  Daskalakis, Z.J.

Desynchronization of autonomic response and central autonomic network connectivity in posttraumatic stress disorder
Thome, J. · Densmore, M. · Frewen, P.A. · McKinnon, M.C. · Théberge, J. · Nicholson, A.A.

Dynamic casual modeling in PTSD and its dissociative subtype: Bottom-up versus top-down processing within fear and emotion regulation circuitry 
Nicholson, A.A. · Friston, K.J. · Zeidman, P. · Harricharan, S. · McKinnon, M.C. · Densmore, M. · Neufeld, R.W.J. · Théberge, J. · Corrigan, F. · Jetley, R. · Spiegel, D. · Lanius, R.A.

The impact of obesity on neuropsychological functioning in adults with and without major depressive disorder
Restivo, M. · McKinnon, M.C. · Frey, B.N. · Hall, G. · Syed, W. · Taylor, V.

+The innate alarm system in PTSD: Conscious and subconscious processing of threat
Lanius, R.A. ·
Rabellino, D. · Boyd, J.E. ·  Harricharan, S. · Frewen, P.A. · McKinnon, M.C.

Methylene blue treatment for residual symptoms of bipolar disorder: Randomised crossover study
Alda, M. · McKinnon, M.C. · Blagdon, R. · Garnham, J. · MacLellan, S. · O’Donovan, C. · Hajek, T. · Nair, C. · Dursun, S. · MacQueen, G.

+Mindfulness-based treatments for posttraumatic stress disorder: A review of the treatment literature and neurobiological evidence 
Boyd, J.E. · Lanius, R.A. · McKinnon, M.C.

+Neural correlates of heart rate variability in PTSD during sub- and supraliminal processing of trauma-related cues
Rabellino, D.
  ·  D’Andrea, W.  · Siegle, G. ·  Frewen, P.A.  ·  Minshew, R.  ·  Densmore, M.  ·  Neufeld, R.J.  ·  Théberge, J. ·  McKinnon, M.C. ·  Lanius, R.A.

The neurobiology of emotion regulation in posttraumatic stress disorder: Amygdala downregulation via real-time fMRI neurofeedback
Nicholson, A.A. · Rabellino, D. · Densmore, M. · Frewen, P.A. · Paret, C. · Kluetsch, R. · Schmahl, C. · Théberge, J. · Neufeld, R. · Mckinnon, M.C. · Reiss, J. · Jetley, R. · Lanius, R.A.

The neurobiology of PTSD
Lanius, R.A. · Olff, M.

+Neuroimaging the traumatized self: fMRI reveals altered response in cortical midline structures and occipital cortex during visual and verbal self- and other-referential processing in women with PTSD
Frewen, P.A. · Thornley, E. · Rabellino, D. · Lanius, R.A.

Neuroimaging the traumatized self: Neural correlates of self- and other-referential processing in women with childhood trauma-related PTSD
Frewen, P.A. · Thornley, E. · Rabellino, D. · Lanius, R.A.

Plastic Modulation of Intrinsic Neural Networks in PTSD through Amygdala Downregulation via Real-Time fMRI Neurofeedback
Lanius, R.A. · Nicholson, A.A. · Rabellino, D. · Densmore, M. · Frewen, P.A. · Paret, C. · Kluetsch, R.C. · Schmahl, C. · Théberge, J. · Neufeld, R.J. · McKinnon, M.C. · Reiss, J. · Rakesh, J.

Posttraumatic Stress Disorder (PTSD) in: Psychiatry in Primary Care: A Concise Canadian Pocket Guide (Second Edition)
Schiavone, F.L. · Lanius, R.A. 

+Relation between patterns of intrinsic network connectivity, cognitive functioning, and symptom presentation in trauma-exposed patients with major depressive disorder 
Parlar, M. · Densmore, M. · Hall, G.B. · Frewen, P.A. · Lanius, R.A. · McKinnon, M.C.

Resting State Functional Connectivity of the Innate Alarm System in PTSD
Harricharan, S. · Rabellino, D. · Frewen, P.A. · Densmore, M. · Théberge, J. · Schore, A.N. · Lanius, R.A.

Sensory overload and imbalance: Resting-state vestibular connectivity in PTSD and its dissociative subtype
Harricharan, S. · Nicholson, A.A. · Densmore, M. · Théberge, J. · McKinnon, M.C. · Neufeld, R.W.J. · Lanius, R.A.

Six-year follow-up of the treatment of patients with dissociative disorders study
Myrick, A.C. · Webermann, A.R. · Loewenstein, R.J. · Lanius, R.A. · Putnam, F.W. · Brand, B.L.

2016

Aberrant Functional Connectivity of the Amygdala Complexes in PTSD during Conscious and Subconscious Processing of Trauma-Related Stimuli
Rabellino, D. · Densmore, M. · Frewen, P.A. · Théberge, J. · McKinnon, M.C. · Lanius, R.A.

Alpha oscillation neurofeedback modulates amygdala complex connectivity and arousal in posttraumatic stress disorder
Nicholson, A.A. · Ros, T. · Frewen, P.A. · Densmore, M. · Théberge, J. · Kluetsch, R.C. · Lanius, R.A.

A Recovery-Oriented Care Approach: Weighing the Pros and Cons of a Newly-Built Mental Health Facility. 
Ahern, C. • Bieling, P. • McKinnon, MC. • Langstaff, K. • McNeely, H.

+A review of the relation between dissociation, memory, executive functioning and social cognition in military members and civilians with neuropsychiatric conditions
McKinnon, M.C. ·
Boyd, J.E. · Frewen, P.A. · Lanius, U.F. · Jetly, R. · Richardson, J.D. · Lanius, R.A.

+Dissociative symptoms are associated with reduced neuropsychological performance in patients with recurrent depression and a history of trauma exposure
Parlar, M. · Frewen, P.A. · Oremus, C. · Lanius, R.A. · McKinnon, M.C.

Effect of obesity on cognition in adults with and without mood disorder: Study design and methods
Restivo, M.R. • McKinnon, M.C. • Frey, B.N. • Hall, G.B • Taylor, V.H.

Evidence-based design features improve sleep quality among psychiatric inpatients
Pyrke, R.  · McKinnon, M.C. · McNeely, H. · Ahern, C. · Langstaff, K • Bieling, P.

fMRI functional connectivity of the periaqueductal gray in PTSD and its dissociative subtype
Harricharan, S. · Rabellino, D. · Frewen, P. A. · Densmore, M. · Théberge, J · McKinnon, M.C. · Shore, A.N. · Lanius, R.A.

“I can’t tell whether it’s my hand”: A pilot study of the neurophenomenology of body representation during the rubber hand illusion in trauma-related disorders
Rabellino, D. · Harricharan, S. · Frewen, P.A. · Burin, D. · McKinnon, M.C. · Lanius, R.A.

The innate alarm circuit in post-traumatic stress disorder: Conscious and subconscious processing of fear- and trauma-related cues
Rabellino, D. · Densmore, M. · Frewen, P.A. · Théberge, J. · Lanius, R.A. 

+Moral reasoning in women with post-traumatic stress disorder related to childhood abuse
Nazarov A. · Walaszczyk, V. · Frewen, P.A. · Oremus, C. · Lanius, R.A. · McKinnon, M.C.

Overcoming the challenges inherent in conducting design research in mental health settings: Lessons from St. Joseph’s healthcare, Hamilton’s pre and post-occupancy evaluation
Ahern, C. · McKinnon, M.C. · Bieling, P.J. · McNeely, H. · Langstaff, K.

+Parental bonding and neuropsychological performance are associated with episodic simulation of future events in trauma-exposed patients with major depressive disorder
Parlar, M. · Lee, A. · Haggee, Z. · Rhooms, L. · Lanius, R.A. · McKinnon, M.C.

Unique insula subregion resting-state functional connectivity with amygdala complexes in posttraumatic stress disorder and its dissociative subtype
Nicholson, A.A. • Sapru, I. • Densmore, M. • Frewen, P.A. • Neufeld, R.W. • Théberge, J. • McKinnon, M.C. • Lanius, R.A.

2015

+Comprehension of affective prosody in women with post-traumatic stress disorder related to childhood abuse
Nazarov, A. • Frewen, P.A. • Oremus, C. • Schellenberg, E.G. • McKinnon, M.C.Lanius, R.A.

Dissociation in borderline personality disorder: Disturbed cognitive and emotional inhibition and its neural correlates
Winter, D. • Krause-Utz, A. • Lis, S. • Chiu-De, C. • Lanius, R.A. • Schriner, F. • Bohus, M. • Schmahl, C.

The dissociative subtype of posttraumatic stress disorder: Unique resting-state functional connectivity of basolateral and centromedial amygdala complexes
Nicholson, A.A. • Densmore, M. • Frewen, P.A. • Théberge, J. • Neufeld, R.W. • McKinnon, M.C.Lanius, R.A.

Distinct intrinsic network connectivity patterns of post-traumatic stress disorder symptom clusters
Tursich, M. • Ros, T. • Frewen, P.A. • Kluetsch, R.C. • Calhoun, V. D. • Lanius, R.A.

Effect of direct eye contact in women with PTSD related to interpersonal trauma: Psychophysiological interaction analysis of connectivity of an innate alarm system
Steuwe, C. • Daniels, J.K. • Frewen, P.A. • Densmore, M. • Théberge, J. • Lanius, R.A.

+Effects of electroconvulsive therapy on cognitive functioning in patients with depression: Protocol for a systematic review and meta-analysis
Oremus, C. • Oremus, M. • McNeely, H. • Losier, B. • Parlar, M. • King, M. • Hasey, G. • Fervaha, G. • Graham, A.C. • Gregory, C. • Hanford, L. • Nazarov, A. • Restivo, M. • Tatham, E. • Truong, W. • Hall, G.B. • Lanius, R.A.McKinnon, M.C.

Emotional memory in pregnant women at risk for postpartum depression
Williams, M.E. • Becker, S. • McKinnon, M.C. • Wong, Q. • Cudney, L.E. • Steiner M. • Frey, B.N.

Geriatric borderline personality disorder in the era of DSM-5 and ICD-11
Meusel, L.M • McKinnon, M.C. • Bieling, P.

Intrinsic connectivity networks in post-traumatic stress disorder during sub- and supraliminal processing of threat-related stimuli
Rabellino, D. • Tursich, M. • Frewen, P.A. • Daniels, J.K. • Densmore, M. • Théberge, J. • Lanius, R.A.

Latent profile analysis and principal axis factoring of the DSM-5 dissociative subtype
Frewen, P.A. • Brown, M.F. • Steuwe, C. • Lanius, R.A.

The neural correlates of memory for a life-threatening event: An fMRI study of passengers from flight AT236
Palombo, D.J. • McKinnon, M.C. • McIntosh, A.R. • Anderson, A.K. • Todd, R.M. • Levine, B.

The relationship between insight and autobiographical memory for emotional events in schizophrenia
MacDougall, A.G. • McKinnon, M.C. • Herdman, K.A. • King, M.J. • Kiang, M.

Restoring large-scale brain networks in PTSD and related disorders: A proposal for neuroscientifically-informed treatment interventions
Lanius, R.A. • Frewen, P.A. • Tursich, M. • Jetly, R. • McKinnon, M.C.

+Role of morality in the experience of guilt and shame within the armed forces
Nazarov, A.• Jetly, R. • McNeely, H. • Kiang, M. • Lanius, R.A.McKinnon, M.C.

Structural brain aberrations associated with the dissociative subtype of post-traumatic stress disorder
Daniels, J.K. • Frewen, P.A. • Théberge, J. • Lanius, R.A.

Threat of death and autobiographical memory: A study of passengers from flight AT236
McKinnon, M.C. • Palombo, D.J. • Nazarov, A.• Kumar, N. • Khuu, W. • Levine, B.

Trauma and PTSD: setting the research agenda
Olff, M. • Armour, C. • Brewin, C. • Cloitre, M. • Ford, J.D. • Herlihy, J. • Lanius, R.A. • Rosner, R. • Schmidt, U. • Turner, S.

Trauma-related altered states of consciousness (TRASC) and functional impairment I: Prospective study in acutely traumatized persons
Frewen, P.A. • Hegadoren, K. • Coupland, N. • Rowe, B. • Neufeld, R. • Lanius, R.A.

Trauma-related dissociation and altered states of consciousness: A call for clinical, treatment, and neuroscience research
Lanius, R.A.

Treatment of complex dissociative disorders: A comparison of interventions reported by community therapists versus those recommended by experts
Myrick, A.C. • Chasson, G.S. • Lanius, R.A. • Leventhal, B. • Brand, B.L.

2014

A social-cognitive-neuroscience approach to PTSD: Clinical and research perspectives
Lanius, R.A. • Frewen, P.A. • Nazarov, A. • McKinnon, M.C.

A systematic review of the reporting of sample size calculations and corresponding data components in observational functional magnetic resonance imaging studies
Guo, Q. • Thabane, L. • Hall, G. • McKinnon, M.C. • Goeree, R. • Pullenayegum, E.

+Alterations in empathic responding among women with posttraumatic stress disorder associated with childhood trauma
Parlar, M. • Frewen, P.A. • Nazarov, A. • Oremus, C. • MacQueen, G. • Lanius, R.A.McKinnon, M.C.

Altered connectivity within the salience network during direct eye gaze in PTSD
Thome, J. • Frewen, P.A. • Daniels, J.K. • Densmore, M. • Lanius, R.A.

Association of trauma exposure with proinflammatory activity: A transdiagnostic meta-analysis
Tursich, M.• Neufeld, R.W. • Frewen, P.A. • Harricharan, S • Kibler, J.L. • Rhind, S.G. • Lanius, R.A.

Chronic complex dissociative disorders and borderline personality disorder: Disorders of emotion dysregulation?
Brand, B.L. • Lanius, R.A.

Effect of direct eye contact in PTSD related to interpersonal trauma: An fMRI study of activation of an innate alarm system
Steuwe, C. • Daniels, J.K. • Frewen, P.A. • Densmore, M. • Pannasch, S. • Beblo, T. • Reiss, J. • Lanius, R.A.

Plastic modulation of PTSD resting-state networks and subjective wellbeing by EEG neurofeedback
Kluetsch, R.C. • Ros, T. • Théberge, J. • Frewen, P.A. • Calhoun, V.D. • Schmahl, C. • Jetly, R. • Lanius, R.A.

The reporting of observational clinical functional magnetic resonance imaging studies: A systematic review
Guo, Q. • Parlar, M. • Truong, W. • Hall, G. • Thabane, L. • McKinnon, M.C. • Goeree, R. • Pullenayegum, E.

Resting-state neuroimaging studies: A new way of identifying differences and similarities among the anxiety disorders?
Peterson, A. • Thome, J. • Frewen, P.A. • Lanius, R.A.

Test-retest reliability of N400 event-related brain potential measures in a word-pair semantic priming paradigm in patients with schizophrenia
Boyd, J.E. • Patriciu, I. • McKinnon, M.C. • Kiang, M.

+Theory of mind performance in women with posttraumatic stress disorder related to childhood abuse
Nazarov, A. • Frewen, P.A. • Parlar, M. • Oremus, C • MacQueen, G. • McKinnon, M.C.Lanius, R.A.

Trauma-related altered states of consciousness: Exploring the 4-D model
Frewen, P.A. • Lanius, R.A.

Trauma-related altered states of consciousness in women with BPD with or without co-occurring PTSD
Frewen, P.A. • Kleindienst, N. • Lanius, R. • Schmahl, C.

Tuning pathological brain oscillations with neurofeedback: A systems neuroscience framework
Ros, T. • Baars, B.J. • Lanius, R.A. • Vuilleumier, P.