Addictions Research

Homewood Research Institute is conducting addictions research focused on improving practice and outcomes. Dr. James MacKillop, HRI Senior Scientist, Peter Boris Chair in Addictions Research at McMaster University, Director, Peter Boris Centre for Addictions Research and Director, Michael E. DeGroote Centre for Medicinal Cannabis Research, is guiding the development of the research program with Homewood clinical leaders and HRI staff.


+ Funded by HRI
* Conducted at Homewood
Underlined Research Trainees


Availability of legalized cannabis reduces demand for illegal cannabis among Canadian cannabis users: evidence from a behavioural economic substitution paradigm (in press)
Amlung, M.T. · MacKillop, J.

Cannabidiol as a novel candidate alcohol use disorder pharmacotherapy: a systematic review (in press)
Turna, J. · Syan, S.K. · Frey, B.N. · Rush, B. · Costello, J. · Weiss, M. · MacKillop, J.

Clarifying the relationship between alcohol demand and alcohol-related relative reinforcement and driving after drinking in a Canadian community sample (in press)
Patel, H. · Reed, D. · MacKillop, J. · Amlung, M.T.

Elevated behavioral economic demand for alcohol in co-users of cannabis and alcohol (in press)
Morris, V. · Patel, H. · Vedelago, L. · Reed, D.D. · Aston, E.R. · Metrik, J. · MacKillop, J. · Amlung, M.

Genome-wide association analyses of risk tolerance and risky behaviors in over one million individuals identify hundreds of loci and shared genetic influences (in press)
Linner, R.K. et al [>15 authors]

Genome-wide association studies of impulsive personality traits (BIS-11 and UPPSP) and drug experimentation in up to 22,861 adult research participants identify loci in the CACNA1l and CADM2 genes (in press)
Sanchez-Roige, S. · Fontanillas, P. · Elson, S. · Gray, J. · de Wit, H. · MacKillop, J. · Palmer, A.A.

Urinary tetrahydrocannabinol is associated with poorer working memory performance and alterations in associated brain activity (in press)
Owens, M.M. · McNally, S. · Petker, T. · Amlung, M.T. · Balodis, I.M. · Sweet, L.H. · MacKillop, J.


Age sensitive associations of adolescent substance use with amygdalar, ventral striatum, and frontal volumes in young adulthood
Windle, M. · Gray, J.C. · Lei, K.M. · Barton, A.W. · Brody, G. · Beach, S.R.H. · Galván, A. · MacKillop, J. · Clark, U.S. · Sweet, L.H.

Alcohol devaluation has dissociable effects on distinct components of alcohol behaviour
Rose, A.K. · Brown, K. · MacKillop, J. · Field, M. · Hogarth, L.

Distinct functional and structural neural underpinnings of working memory
Owens, M.M. · Duda, B. · Sweet, L.H. · MacKillop, J.

Effects of neuromodulation on cognitive performance in individuals exhibiting addictive behaviour: A systematic review protocol
Naish, K.R. · Vedelago, L. · MacKillop, J. · Amlung, M.T.

Enhancing motivation in behavioral and cognitive therapy
MacKillop, J. · Vanderbroek, L. · Munn, C.

Evidence-based treatment for alcohol use disorders: A review through the lens of the theory x efficacy matrix
MacKillop, J. · Stojek, M.M. · VanderBroek, L. · Owens, M.

Genetic analysis of impulsive personality traits: Examination of a priori candidates and genome-wide variations +
Gray, J.C. · MacKillop, J.  · Weafer, J. · Hernandez, K.M. · Gao, J. · Palmer, A.A. · de Wit, H.

Negative urgency moderates reactivity to laboratory stress inductions
Owens, M.M. · Amlung, M.T. · Stojek, M. · MacKillop, J.

Price elasticity of illegal vs. legal cannabis: a behavioral economic substitutability analysis
Amlung, M. · Reed, D.D. · Morris, V. · Aston, E.R. · Metrik, J. · MacKillop, J. · 

Reinforcing value and hypothetical behavioural economic demand for food and their relation to BMI
Epstein, L.H. · Paluch, R.A. · Carr, K.A. · Temple, J.L. · Bickel, W.K. · MacKillop, J.


Association between cannabis use and methadone maintenance treatment outcomes: An investigation into sex differences
Zielinski, L. · Bhatt, M. · Sanger, N. · Plater, C. · Worster, A. · Varenbut, M. · Daiter, J. · Pare, G. · Marsh, D.C. · Desai, D. · MacKillop, J. · Steiner, M. · McDermid Vaz, S. · Thabane, L. · Samaan, Z.

Cannabinoid receptor gene polymorphism (rs2023239) associated with demand for marijuana
Aston, E. · Knopik, V.S. · McGeary, J. · MacKillop, J. · Metrik, J.

Commentary: Delay discounting and smoking: Robust correlation, but uncertain causation +
MacKillop, J. · Munafò, M.R.

Effects of varenicline versus transdermal nicotine replacement therapy on cigarette demand on quit day in individuals with substance use disorders
Murphy, C · MacKillop, J. · Martin, R.A. · Tidey, J.W. · Colby, S.M. · Rohsenow, D.J.

Elevated behavioral economic demand for alcohol in a community sample of heavy drinking smokers. +
Amlung, M.T.  · MacKillop, J. · Monti, P.M.  · Miranda Jr., R.

Family-centered prevention ameliorates the longitudinal association of poverty with hippocampal and amygdalar volumes in adulthood
Brody, G.H. · Gray, J. · Yu, T. · Barton, A.W. · Beach, S.R.H. · Galván, A. · MacKillop, J. · Windle, M. · Chen, E. · Miller, G.E. · Sweet, L.H.

Genetic influences on ADHD symptom dimensions: Examination of a priori candidates, gene-based tests, genome-wide variation, and SNP heritability+
Bidwell, L.C. · Gray, J.C. · Weafer, J. · Palmer, A.A. · de Wit, H. · MacKillop, J.

Genome-wide association study of Alcohol Use Disorder Identification Test (AUDIT) scores in 20,328 research participants of European ancestry +
Sanchez-Roige, S. ·  Fontanillas, P. ·  S.L · the 23andMe Research Team  ·  Gray, J.C. · de Wit, H. ·  Davis, L.K. · MacKillop, J. · Palmer, A.A.

Integrating psychological and pharmacological treatments for addictive disorders
MacKillop, J. · Kenna, G.A. · Leggio, L. · Ray, L.A.

Latent factor structure of a behavioral economic marijuana demand curve +
Aston, E. · Farris, S.G. · MacKillop, J. · Metrik, J.

Multidimensional Assessment of Impulsivity in Relation to Obesity and Food Addiction+
VanderBroek-Stice, L. · Stojek, M.M.K. · Beach, S.R.H. · vanDellen, M.R. · MacKillop, J.

Neural Correlates of Graphic Cigarette Warning Labels Predict Smoking Cessation Relapse
Owens, M.M. · MacKillop, J. · Gray, J.C. · Hawkshead, B.E. · Murphy, C.M. · Sweet, L.H.

Pathways Linking Adverse Childhood Experiences to Cigarette Smoking Among Young Black Men: A Prospective Analysis of the Role of Sleep Problems and Delayed Reward Discounting
Oshri, A. · Kogan, S.M. · Liu, S. · Sweet, L. · MacKillop, J.

Relative reinforcing value of food and delayed reward discounting in obesity and disordered eating: A systematic review +
Stojek, M.M.K. · MacKillop, J.

Self-control depletion and nicotine deprivation as precipitants of smoking cessation failure: A human laboratory model
Heckman, B.W. · Alderson MacQueen, D. · Marquinez, N.S. · MacKillop, J. · Bickel, W.K. · Brandon, T.H.

The association between age of onset of opioid use and comorbidity among opioid dependent patients receiving methadone maintenance therapy
Naji, L. · Dennis, B. · Bawor, M. · Varenbut, M. · Daiter, J. · Plater, C. · Pare, G. · Marsh, D.C. · Worster, A. · Desai, D. · MacKillop, J. · Thebane, L. · Samaan, Z.

The influence of substance use on depressive symptoms among young adult black men: The sensitizing effect of early adversity: Depressive Symptoms and Substance Use in Black Men
Kogan, S. · Cho, J. · Oshri, A. · MacKillop, J.

The Neuroeconomics of Tobacco Demand: An Initial Investigation of the Neural Correlates of Cigarette Cost-Benefit Decision Making in Male Smokers
Gray, J.C. · Amlung, M.l · Owens, M.M. · Acker, J. · Brown, C.L. · Brody, G.H. · Sweet, L.H. · MacKillop, J.


Adaptation of an Acute Psychiatric Unit to a Concurrent Disorders Unit to Increase Capacity and Improve Patient Care
Raymond, H. · Amlung, M. · De Leo, J.A. · MacKillop, J.

Association between cannabis use and treatment outcomes in patients receiving methadone maintenance treatment: A systematic review protocol
Zielinski, L. · Bhatt, M. · Eisen, R. · Perera, S. · Bhatnagar, N. · MacKillop, J. · Steiner, M. · McDermid Vaz, S. · Thabane, L. · Samaan, Z.

Associations between nicotine dependence, anhedonia, urgency and smoking motives
Roys, M. · Weed, K. · Carrigan, M. · MacKillop, J.

Attention deficit hyperactivity disorder and monetary delay discounting: A meta-analysis of case-control studies
Jackson, J.N.S. • MacKillop, J.

Corrigendum to “DRD2/ANKK1 TaqI A genotype moderates the relationship between alexithymia and the relative value of alcohol among male college binge drinkers” [Pharmacol. Biochem. Behav. 102 (2012) 471–476]
Wahlstrom, L.C. · McChargue, D.E. · MacKillop, J.

Cue-Elicited Increases in Incentive Salience for Marijuana: Craving, Demand, and Attentional Bias
Metrik, J. · Aston, E. · Kahler, C.W. · Rohsenow, D.J. · McGeary, J.E. · Knopik, V.S. · MacKillop, J.

Delay discounting and addiction:  A critical review and identification of emerging priorities
Amlung, M. · MacKillop, J.

Initial examination of priming tasks to decrease delay discounting
Sheffer, C.E. · MacKillop, J. · Fernandez, A. · Christensen, D. · Bickel, W.K. · Johnson, M. W. · Panissidi, L. · Pittman, J. · Franck, C.T. · Williams, J. · Mathew, M.

Interactive relationships between sex-related alcohol expectancies and delay discounting on risky sex
Celio, M.A. • MacKillop, J. • Caswell, A.J. • Mastroleo, N.R. • Kahler, C.W. • Barnett, N.P. • Colby, S.M. • Operario, D. • Monti, P.M.

Interrelationships among parental family history of substance misuse, delay discounting, and personal substance use
VanderBroek, L. • Acker, J. • Palmer, A.A. • de Wit, H. • MacKillop, J.

Interrelationships between Marijuana Demand and Discounting of Delayed Rewards: Convergence in Behavioral Economic Methods
Aston, E. · Metrik, J. · Amlung, M. · Kahler, C.W. · MacKillop, J.

Steep Delay Discounting and Addictive Behavior: A Meta-Analysis of Continuous Associations: Delay discounting and addiction
Amlung, M. · Vedelago, L. · Acker, J. · Balodis, I. · MacKillop, J.

Steep discounting of delayed monetary and food rewards in obesity: A meta-analysis
Amlung, Michael T. • Petker, T. • Jackson, J. • Balodis, M. • MacKillop, J.

Syntax for calculation of discounting indices from the Monetary Choice Questionnaire and Probability Discounting Questionnaire
Gray, J.C. · Amlung, M.T. · Palmer, A.A. · MacKillop,  J.

The behavioral economics and neuroeconomics of alcohol use disorders
MacKillop, J.

The latent structure of impulsivity: Impulsive choice, impulsive action, and impulsive personality traits
MacKillop, James · Weafer, J. · Gray, J.C. · Oshri, A. · Palmer, A.A. · de Wit, H.

The Substitutability of Cigarettes and Food: A Behavioral Economic Comparison in Normal Weight and Overweight or Obese Smokers
Murphy, C. · Owens, M.M. · Sweet, L.H. · MacKillop, J.


An initial investigation of associations between dopamine-linked genetic variation and smoking motives in African Americans
Bidwell, L.C. • McGreary, J.E. • Palmer, R.H.C. • Knopik, V.S. • MacKillop, J.

Area under the curve as a novel metric of behavioral economic demand for alcohol
Amlung, M.T. • Yurasek, A. • McCarty, K.N. • MacKillop, J. • Murphy, J.G.

A social network analysis approach to alcohol use and co-occurring addictive behavior in young adults
Meisel, M.K. • Clifton, A.D. • MacKillop, J. • Goodie, A.S.

Behavioral economic analysis of stress effects on acute motivation for alcohol
Owens, M.M. • Ray, L.A. • MacKillop, J.

Behavioral economic decision making and alcohol-related sexual risk behavior
MacKillop, J. • Celio, M.A. • Mastroleo, N.R. • Kahler, C.W. • Operario, D. • Colby, S.M. • Barnett, N.P. • Monti, P.M.

Behavioral economic predictors of brief alcohol intervention outcomes
Murphy, J.G. • Dennhardt, A.A. • Yurasek, A.M. • Skidmore, J.R. • Martens, M.P. • MacKillop, J. • McVeditt-Murphy, M.E.

Childhood physical and sexual abuse and social network patterns on social media: Associations with alcohol use and problems among young adult women
Oshiri, A. • Himelboim, I. • Kwon, J.A. • Sutton, T.E. • MacKillop, J.

D-cycloserine to enhance extinction of cue-elicited craving for alcohol: A translational approach
MacKillop, J. • Few, L.R. • Stojek, M.K. • Murphy, C.M. • Malutinok, S.F. • Johnson, F.T. • Hofmann, S.G. • Swift, R.M. • McGreary, J.E. • Monti, P.M.

Further evidence of close correspondence for alcohol demand decision making for hypothetical and incentivized rewards
Amlung, M.T. • MacKillop, J.

Further validation of a marijuana purchase task
Aston, E.R. • Metrik, J. • MacKillop, J.

Genetic influences on delay discounting in smokers: Examination of a priori candidates and exploration of dopamine-related haplotypes
MacKillop, J. • Gray, J.C. • Bidwell, L.C. • Bickel, W.K. • Sheffer, C.E. • McGreary, J.E.

Impulsive delayed reward discounting as a genetically-influenced target for drug abuse prevention: A critical evaluation
Gray, J.C. • MacKillop, J.

Initial development of a brief behavioral economic assessment of alcohol demand
Owens, M.M. • Murphy, C.M. • MacKillop, J.

NCAM1-TTC12-ANKK1-DRD2 variants and smoking motives as intermediate phenotypes for nicotine dependence
Bidwell, L.C. • McGeary, J.E. • Gray, J.C. • Palmer, R.H.C. • Knopik, V.S • MacKillop, J.

NCAM1-TTC12-ANKK1-DRD2 polymorphisms and smoking motives as intermediate phenotypes for nicotine dependence
Bidwell, L.C. • McGeary, J.E. • Gray, J.C. • Palmer, R.H.C. • Knopik, V.S • MacKillop, J.

Predictive validity of a cigarette purchase task in a randomized controlled trial of contingent vouchers for smoking in individuals with substance use disorders
MacKillop, J. • Murphy, C.M. • Martin, R.A. • Stojek, M. • Tidey, J.W. • Colby, S.M. • Rohsenow, D.J.

Stress, cues, and eating behavior: Using drug addiction paradigms to understand motivation for food
Stojek, M.K. • Fischer, S.F. • MacKillop, J.

The relationship between alcohol consumption, perceived stress, and CRHR1 genotype on the hypothalamic-pituitary-adrenal axis in rural African Americans
Obasi, E.M. • Shirtcliff, E.A. • Brody, G.H. • MacKillop, J. • Pittman, D.M. • Cavanagh, L. • Philibert, R.A.

Using behavior economics to understand alcohol use disorders: A concise review and identification of research priorities
Gray, J.C. • MacKillop, J.

Willingness to provide support for a quit attempt: A study of partners of smokers
van Dellen, M.R. • Boyd, S.M. • Ranby, K.W. • MacKillop, J. • Lipkus, I.M.


Biobehavioral mechanisms of topiramate’s effects on alcohol use: An investigation pairing laboratory and ecological momentary assessments
Miranda, R. • MacKillop, J. • Treloar, H. • Blanchard, A. • Tidey, J.W. • Swift. R.M. • Chun, T. • Rohsenow, D.J. • Monti, P.M.