News

HRI scientist awarded funding to advance promising trauma research

Cognitive tool aims to help veterans and military members

On February 1, Homewood Research Institute (HRI) announced the expansion of vital research that provides hope for people with post-traumatic stress disorder (PTSD).

Early studies led by HRI among inpatients being treated for PTSD suggest that a cognitive training program called Goal Management Training (GMT) helps to reduce symptoms common among people with PTSD, including difficulty with memory, attention, planning and organization.

Thanks to a three-way funding partnership between the Military Casualty Support Foundation, The Cowan Foundation, and RBJ Schlegel Holdings, research will now be expanded to two outpatient clinics in Ontario to evaluate the utility of GMT among military members and veterans with PTSD.

Dr. Margaret McKinnon is Homewood Research Chair in Mental Health and Trauma and the principal investigator behind the GMT studies. She hopes to replicate early findings from inpatient studies among outpatient groups. Her team will evaluate the impact of GMT in the military population at Operational Stress Injury clinics in both Toronto and London.

The introduction of GMT among military professionals is timely: Veterans Affairs Canada reports that nearly 20,000 veterans and armed forces members have now been diagnosed with PTSD.1

Related reading:
Goal therapy treatment helps ease life for veterans with PTSD, CBC
(February 8, 2019)

Further funding to benefit public safety personnel

On February 8, McMaster University announced that Dr. McKinnon was also the recipient of a one-year $150,000 grant from the Canadian Institutes of Health Research (CIHR). McKinnon is one of 22 researchers to receive funding to support the advancement of research that will help people with post-traumatic stress injuries.

Importantly, Dr. McKinnon will focus her studies on public safety personnel – including paramedics, correctional workers, police officers and firefighters – who are frequently exposed to traumatic events that increase their risk of developing post-traumatic stress injuries. A randomized control trial will explore how GMT can benefit public safety workers with PTSD and co-morbid conditions.

Related reading:
Wilfrid Laurier, Guelph researchers receive grants to study PTSD in public safety workers, CBC
(February 8, 2019)
France and Hamilton team up to study depression, The Hamilton Spectator
(February 14, 2019)

References

  1. https://www.veterans.gc.ca/eng/about-us/statistics/8-0

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How Grateful Patients are Giving Back to Help Others

Research demonstrates that the practice of gratitude improves immune function, lowers blood pressure, and reduces the lifetime risk for depression, anxiety and substance use disorders.

Patients recovering from mental illness and addiction often ask how they can show their gratitude for a clinician, staff member or other individual who has played a key role in their recovery. We are pleased to announce a new program that allows patients who have benefitted from our research to do just that.

Homewood Research Institute (HRI) has launched the Grateful Patient Program, a donation program that enables patients to recognize someone special. And with every donation, grateful patients will also support others following in their footsteps on the road to recovery.

Patients are invited to donate and share their comments about an individual who contributed to making their recovery journey a success. Honourees will receive a letter of recognition, and all funds will support research at HRI that is designed to help future patients get better, faster.

Every donation will support the discovery of new treatments, the refinement of existing practices and the evaluation of alternative treatment approaches – all in pursuit of better mental health for Canadians.

The Grateful Patient Program is one more way that patients can play a vital role in advancing HRI’s vision of world where no life is held back or cut short by mental illness or addiction. And it offers people in recovery another means of practicing gratitude and celebrating those who have helped them along the way.

To make a one-time gift or monthly donation of gratitude today, click here.

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Press Release: New Study Provides Hope for Those Suffering from Post-Traumatic Stress Disorder

Guelph, February 1, 2019 – Trauma is more complex than originally thought. People diagnosed with post-traumatic stress disorder (PTSD) often experience changes in cognitive functioning, such as difficulty with memory, attention, concentration, planning and organization. Despite the fact that these challenges can severely impact one’s ability to function at work, school, home or in social settings, few studies have investigated treatments aimed specifically at improving thinking skills among individuals with PTSD.

A new study led by Homewood Research Institute (HRI) is exploring an innovative way to address this gap, treating the symptoms of PTSD through a cognitive training program called Goal Management Training (GMT).

GMT aims to reduce the symptoms of PTSD by helping people recover the ability to stop automatic responding, monitor progress on tasks and goals, and achieve those goals. The training has been used successfully in other patient populations – including people with brain injuries – to improve concentration, memory, and organization. This is one of the first times that the GMT program has been tested among those diagnosed with PTSD.

Preliminary results from studies involving patients receiving treatment for PTSD at Homewood Health suggest that GMT helps to improve thinking speed, memory and the pursuit of personal goals. GMT also led to reductions in depression and self-reported cognitive difficulties. Recently, GMT research has expanded and is now being trialed among individuals in the community with a history of military-related trauma and those who have worked as public safety personnel, such as firefighters, paramedics or police officers.

“Based on our studies to date, GMT holds great promise for improving quality of life and cognitive function for individuals with PTSD,” says Dr. Margaret McKinnon, Homewood Research Chair in Mental Health and Trauma, Associate Professor & Associate Chair of Research in the Department of Psychiatry and Behavioural Neurosciences at McMaster University, Psychologist in the Mood Disorders Program at St. Joseph’s Healthcare in Hamilton, and the principal investigator behind the study. “

But she cautions: “It does not replace standard treatment for PTSD, but rather focuses on cognitive function and quality of life.”

This vital research is made possible thanks to the generous support of The Military Casualty Support Foundation, The Cowan Foundation, and RBJ Schlegel Holdings, who have formed a three-way partnership and will collectively invest $200,000 over two years to expand GMT research in outpatient clinics treating military members and veterans to determine if previous findings can be replicated in non-residential settings.

“GMT provides hope for those who are suffering from PTSD,” says Theresa Hacking, President of the Military Casualty Support Foundation.

“We want to help military members and their families now, and GMT appears to be the way forward. We are honoured to pioneer this new treatment.”

In the coming months, HRI will implement Goal Management Training programs in both Toronto and London. The nine-week program will run year-round and will invite 12 participants per session. Doing so will not only help researchers understand the impact of GMT in outpatient environments, but it will allow individuals to access a program that may prove to be significantly beneficial to their quality of life.

“On behalf of The Cowan Foundation Board, we are proud to partner and support this program,” says Mary D’Alton, Executive Director of The Cowan Foundation.

“It closely aligns with the Foundation’s goal of improving the lives of Canadians, including those experiencing PTSD.”

“We are very pleased with this unique opportunity to partner with the Military Casualty Support Foundation, RBJ Schlegel Holdings and HRI,” says Heather McLachlin, President of Cowan Insurance Group.

“We see this research as having unlimited potential for those dealing with PTSD and their families.”

“HRI is grateful to The Cowan Foundation, the Military Casualty Support Foundation and RBJ Schlegel Holdings for their investment in this project,” says Roy Cameron, Executive Director of Homewood Research Institute.

“Their support enables Dr. McKinnon and her team to offer GMT to military members in a way that makes it possible to use evaluation to refine the way this new service is delivered as it rolls out.”

For more information, please contact:

Dr. Roy Cameron 
Executive Director
Homewood Research Institute
Office: 519-824-1010, ext. 32578
RCameron@homewoodhealth.com


Dr. Margaret McKinnon
Homewood Research Chair in Mental Health and Trauma
Associate Professor & Associate Chair, Research, Department of Psychiatry and Behavioural Neurosciences, McMaster University Psychologist, Mood Disorders Program
St. Joseph’s Healthcare in Hamilton
Homewood Research Institute
Office: 519-824-1010, ext. 32252
MMckinnon@homewoodhealth.com

 

HRI Senior Scientist contributes to national discussions on the legalization of cannabis

As Canada enters its second month following the nationwide legalization of cannabis, Dr. James MacKillop, HRI Senior Scientist and Director of the Peter Boris Centre for Addictions Research and the Michael G. DeGroote Centre for Medicinal Cannabis Research, is encouraging Canadians to think critically about cannabis use.

“Legalization has prompted an intense national discussion on cannabis, which is a very good thing”, says Dr. MacKillop.

“But the discussion needs to focus on facts and evidence, rather than opinion and anecdote. We need to think critically about where cannabis fits into the larger landscape, both as a recreational drug and as a potential treatment.”

In the news

Dr. MacKillop has contributed to a number of influential discussions aimed at helping Canadians make informed decisions about marijuana use:

Dr. MacKillop also led a recent roundtable discussion exploring the impact, benefits and risks of cannabis, as well as opportunities to advance research. Hosted by the Michael G. DeGroote Centre for Medicinal Cannabis Research, the roundtable involved stakeholders from across the mental health and addiction research community.

The bottom line: more research funding is needed to separate fact from fiction when it comes to cannabis use for both medical and recreational purposes.

Dr. MacKillop is recognized as a leading national expert on cannabis. His research integrates perspectives from psychology, psychiatry, cognitive neuroscience, and behavioral genetics to improve our understanding of psychoactive drugs.

Recently, Dr. MacKillop was awarded the 2018 Anne and Neil McArthur Research Award from St. Joseph’s Healthcare.

This award is presented to an internationally recognized researcher whose field of study is also a focus of research at St. Joseph’s Healthcare.

Congratulations, Dr. MacKillop, on this much-deserved honour.

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Advancing research for military and veteran mental health

Military members and veterans are among those most vulnerable to post-traumatic stress disorder (PTSD). There is an urgent need to identify new and innovative treatments that will help military members suffering from trauma-related illnesses.

The Canadian Institute for Military and Veteran Health Research (CIMVHR) hosts an annual forum, bringing together thought leaders from the government, research institutions, industry and philanthropic sectors. A major goal of the forum is to understand how new research findings can be used to help military personnel, veterans and their families.

Here are some highlights outlining HRI’s contributions to this year’s forum.

Building a national network for trauma research

HRI has been bringing leaders together to identify research needs that will have the greatest benefit for people with PTSD.

On October 16, Dr. Margaret McKinnon, Homewood Chair in Mental Health and Trauma, led an interactive workshop, building on a collaborative planning exercise that took place at the 2014 CIMVHR forum. The workshop invited input to establish research priorities for the next four years.

The session attracted a broad range of stakeholders, including individuals with PTSD, scientists, clinicians, military members, public safety professionals, and first responders.

Dr. McKinnon and Dr. Ruth Lanius shared findings from research conducted since 2014, and facilitated discussions to shape the next phase of the HRI research program. The session also set the stage for partnering with other organizations, including the Canadian Institute for Public Safety Research and Treatment (CIPSRT), which uses research to improve treatment in first responders.

Leading discussions about cannabis

Dr. James MacKillop, HRI Senior Scientist and Director of the Peter Boris Centre for Addictions Research and the Michael G. DeGroote Centre for Medicinal Cannabis Research appeared as a keynote speaker at this year’s CIMVHR Forum, sharing insights from the latest medical research on cannabis a mere 15 hours before its legalization.

“While there is relatively consistent evidence supporting cannabis as an approach to pain management, that doesn’t mean cannabis use comes without risk,” says Dr. MacKillop.

According to MacKillop, two of the biggest risk factors include:

  1. Impairment, particularly motor coordination impairment, which could lead to motor vehicle collisions and workplace accidents, and
  2. Overconsumption, which can cause delirium and psychosis.

Dr. MacKillop also reminded attendees that – contrary to popular belief – cannabis is addictive.

“Although cannabis is far from being the most addictive drug, its actions in the brain are similar to drugs like alcohol, cocaine and heroin; it affects the same regions that are responsible for reward and motivation.”

Dr. MacKillop is a leading authority on cannabis and has been in the media spotlight recently. Click to read more about his contributions to national discussions about the legalization of cannabis.

HRI Research Trainee receives award for moral injury study

We are pleased to announce that HRI Research Trainee, Alina Protopopescu, was the recipient of the 2018 Editor’s Choice Award at this year’s CIMVHR Forum.

Dr. Stephanie Belanger, Associate Scientific Director of CIMVHR, presents the 2018 Editor’s Choice Award to Alina Protopopescu. (Photo credit: CIMVHR)

Alina, a PhD Candidate in the Research and Clinical Training Stream in the Psychology, Neuroscience and Behaviour Program at McMaster University, received the award for her presentation of recent findings that examined the relationship between childhood abuse and moral injury.

A moral injury may occur when a person is forced by circumstances to act in a way that violates his or her moral standards. For example, consider the soldier who may have no choice but to harm innocent people while stopping a major terrorist assault.

In the presentation, Alina shared results from a study conducted in collaboration with Anthony Battaglia, which suggested that military personnel and veterans who experience childhood emotional abuse may be at risk for developing a moral injury during their service. The findings provide clues as to how we can better treat moral injury, particularly in populations like military members and veterans.

Congratulations, Alina, on your award!

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Using technology to diagnose PTSD and its subtypes

An HRI Research Trainee is using neuroimaging and machine learning to discover how post-traumatic stress disorder (PTSD) is related to patterns of brain activity, and the findings could have important implications for both diagnostic and preventative medicine.

Dr. Andrew NicholsonDr. Andrew Nicholson is a post-doctoral fellow affiliated with Western University, McMaster University and Lawson Health Research Institute. His postdoctoral fellowship is funded jointly by Mitacs Elevate and HRI, and his research focuses on the use of neuroimaging techniques to advance healthcare.

In a recent publication co-authored by HRI Associate Clinical Scientist, Dr. Ruth Lanius, and Homewood Research Chair in Mental Health and Trauma, Dr. Margaret McKinnon, Dr. Nicholson reported findings that suggest technological advances may enable early diagnosis of PTSD and its clinical subtypes.

About the study

Machine learning multivariate pattern analysis predicts classification of posttraumatic stress disorder and its dissociative subtype: a multimodal neuroimaging approach was published last month in Psychological Medicine.

In his study, Nicholson and his team used functional MRIs to document patterns of resting brain activity in three groups:

  1. Individuals with no history of PTSD (healthy control group)
  2. Individuals diagnosed with PTSD, and
  3. Individuals diagnosed with the dissociative subtype of PTSD (PTSD + DS)

The dissociative subtype of PTSD is characterized by symptoms of detachment and emotional numbness. It is different from the more familiar type of PTSD, which often results in difficulty controlling strong emotions and outbursts.

Nicholson’s study found that when patterns of brain activation were fed into a machine learning algorithm, the computer system predicted the classification of PTSD, PTSD + DS ,and healthy controls in new subjects with 91.63% accuracy.

Functional MRI images from Dr. Nicholson’s study show patterns of brain activity that are used to detect and classify a PTSD diagnosis.

How can these findings advance healthcare?

Dr. Nicholson’s findings suggest that distinct patterns of brain activity are associated with specific forms of PTSD. These brain activity patterns are considered unique biomarkers that may aid in the early diagnosis and intervention of PTSD and its subtypes. Nicholson’s findings may also help people with PTSD understand that there is a physical basis for their disorder.

New technologies can help us understand how symptoms of mental illness are related to brain activity. They enable the potential for detecting diagnoses that may not have been previously suspected or considered, and they facilitate expedient and objective diagnoses, opening the door to more individualized treatment approaches.

Dr. Nicholson’s work is unearthing valuable neurobiological clues about how to classify and better treat mental illness. To follow his research, visit drandrewnicholson.com.

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Holiday Giving Banner Image

The holiday season is the perfect time to become a champion and help people struggling with mental illness and addiction.

From now until December 31, we invite you to support HRI’s Holiday Giving Campaign and make a donation that will help us change lives through research. Your donation will help to:

  • Transform mental health and addiction services through research
  • Improve care through the measurement of treatment outcomes in mental health and addiction
  • Engage leading scientists, universities, patients and clinicians
  • Merge research with practice to improve care faster

Meet our Campaign Chair: Janice Lace

Janice worked at Homewood Health Centre for 30 years. As Director of Operations, she collaborated with HRI on a number of research initiatives to improve patient care. We are grateful to Janice for her support and are honoured that she has agreed to serve as our 2018 Campaign Chair.

“I believe the partnership between HRI and Homewood Health has the potential to transform mental health in Canada.” – Janice Lace

HRI Research Day: find out how your donations are used

We welcome you — our community, partners, friends and followers — to learn about studies currently underway on HRI Research Day 2018.

Speak directly with our scientists and research trainees to find out how HRI is helping to fill critical gaps in Canada’s mental health and addiction systems.

Riverslea BuildingHRI Research Day 2018
Tuesday, November 27
11 a.m. to 1 p.m.
HRI Offices, Riverslea Building
150 Delhi Street, Guelph ON

RSVP NOW

New this year: the Darlene Walton Scholarship Fund

We are pleased to announce a new scholarship to support students entering the field of mental health and addiction research.

Darlene WaltonThe Darlene Walton Scholarship Fund honours the legacy of a dear friend to HRI. For 38 years, Darlene worked at Homewood Health Centre, giving her best each day to help patients recover. An avid supporter of HRI, she recognized the importance of training the next generation of researchers to improve care in Canada.

Sadly, Darlene passed away in June of 2018. You can support Darlene’s vision of a brighter future by directing your donation to the Darlene Walton Scholarship Fund when you make a donation online today.

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Upcoming Symposium on Addiction and PTSD

Addiction and post-traumatic stress disorder (PTSD) often occur together, causing debilitating consequences for those affected. There is little consensus among clinicians about how best to treat individuals suffering from both disorders, but new research is providing hope for patients and healthcare providers alike. This will be the focus of an upcoming symposium.

ConferenceIn October, experts from HRI and Homewood Health Centre will discuss the latest science, outcomes and promising practices related to the treatment of co-occurring addiction and PTSD at the 2018 Canadian Society for Addiction Medicine Annual Meeting and Scientific Conference (CSAM).

Each year, CSAM brings together researchers, educators and clinicians from across Canada and around the world. This year, the conference explores the theme “Crisis, Controversy and Change”, shedding light on the urgent need for improvements to mental health and addiction care. Experts from various disciplines will present research and exchange ideas to advance science and treatment.

The joint symposium, coordinated by HRI Research and Evaluation Scientist, Dr. Jean Costello, will feature the following speakers and topics:

  • Dr. Vivian Sarabia, Addiction Physician at Homewood Health Centre, will discuss the leading hypotheses that attempt to explain why PTSD and addiction often occur simultaneously;
  • Sabrina Kaur Syan, a PhD student working alongside HRI Senior Scientist Dr. James MacKillop, will present results from a study that investigates PTSD symptom severity as a predictor of drop-out from inpatient addiction treatment;
  • Dr. Hollam Sutandar, Addiction Psychiatrist at Homewood Health Centre, will discuss a pilot study that examines the use of Cognitive Processing Therapy in treating patients with co-occurring PTSD and addiction; and
  • Dr. Margaret McKinnon, Homewood Research Chair in Mental Health and Trauma, will share findings from a trial investigating the use of Goal Management Training (a cognitive skills training program) in patients with PTSD, as well as patients with co-occurring PTSD and addiction.

This symposium is an excellent example of the collaboration between Homewood Health Centre clinicians and HRI researchers. Together, we are generating findings and bringing new treatment ideas into practice sooner.

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