$1M awarded to HRI scientists studying new treatment for PTSD in first responders

Over the next three years, HRI scientists will receive nearly $1 million to support a study aimed at helping Canada’s public safety personnel (PSP).

A $990,000 grant from the Canadian Institutes of Health Research (CIHR) was awarded to Dr. Margaret McKinnon, Homewood Research Chair in Mental Health and Trauma, and Dr. Ruth Lanius, HRI Consulting Scientist, for their study exploring a new approach to treating PTSD in PSP.

PSP include paramedics, police, firefighters, nurses, correctional officers, and others working in emergency service and first response roles.

The study will test the utility of a cognitive therapy program, called Goal Management Training, in reducing the cognitive and emotional symptoms of PTSD, such as difficulty with memory, concentration and planning, as well as impulsivity and anger. The researchers will measure not only symptom changes among PSP receiving the treatment but also functional outcomes such as return to work and functioning in the family. They will also use MRI technology to examine changes in the brain structure and in brain function before and after treatment.

“The ability to capture very high-resolution images of the brain before and after treatment makes this study unique, and allows us to make the invisible wound of PTSD visible” says Dr. McKinnon.

“Not only can we measure how symptoms change in PSP with PTSD, but we can observe physical changes in the brain structure and function as a result of this treatment.”

A timely announcement

Funding for the study was announced as the COVID-19 pandemic took hold and Canada’s PSP were thrust into the spotlight.

“First responders and healthcare workers are dedicating their lives to society by working on the frontlines amid this global emergency,” says McKinnon.

“We know the pandemic will bring overwhelming trauma to many people working in the healthcare and public safety sectors at this time. It is very powerful to be able to offer hope to those who may be affected by PTSD and to be able to offer hope to our first responder and healthcare communities impacted by COVID-19.”

Focus on real-world application

To date, studies on trauma among PSP have focused on reducing the emotional symptoms of PTSD, such as hypervigilance and anxiety; however, many people are left with cognitive deficits that severely impact day-to-day functioning. These cognitive and emotional symptoms interact leading to difficulties such as poor planning, impulsivity, and problems with anger management”

“Very few studies have actually looked at real-world functioning – for example, the ability to return to work,” says Dr. Ruth Lanius, co-investigator and a Professor at Western University.

“If an individual struggles to process new information, maintain focus, or make a timely decision, their chances of returning to work and normal life are slim to none. We want to find treatments that help to close that gap – new approaches that help people get their quality of life back.”

Generous funding from Military Casualty Support Foundation, the Cowan Foundation, and the Bickell Foundation has been critical to the development of this program of research. Additional funding from the Worker’s Safety Insurance Board of Ontario will allow the team to look at various formats for delivery of GMT, and associated adjunctive treatments.

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Contributing to national discussions about COVID-19 and mental health

Protecting the psychological well-being of our nation during the COVID-19 pandemic has been a priority for anyone working in the field of mental health and addiction.

As the novel coronavirus spread throughout our communities, so too did our anxiety about the future. Prolonged isolation, the loss of loved ones, and financial hardship have placed many at risk of mental illness. For healthcare workers, another threat persists – the threat of moral injury.

Recently, HRI scientists have added to important discussions across Canada about the trauma-related impacts of COVID-19:

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Moral dilemmas and traumatic stress during COVID-19

The COVID-19 pandemic places many people at risk for exposure to potentially traumatic events. Some of us have already faced the loss of a loved one, long-term isolation from family and friends, or perhaps a near-death experience ourselves. But this pandemic brings another type of trauma-related risk: the risk of sustaining a moral injury.

What is moral injury?

A moral injury may occur when a person witnesses, fails to prevent, or engages in an event that violates their personal moral beliefs. Exposure to morally injurious situations has been linked to post-traumatic stress disorder and can bring profound shame, anguish, and guilt that severely disrupts one’s quality of life.

In the context of COVID-19, a moral injury could occur after an individual faces an ethical dilemma that results in harm to another or to oneself. For example:

  • A doctor who must make difficult decisions about how to deploy limited life-saving resources, such as ventilators
  • A healthcare worker who may put their own children at risk by continuing to work
  • An individual who cannot be with a terminally ill loved one due to self-illness or facility restrictions
  • An undiagnosed person who inadvertently infects vulnerable residents in a nursing home

These are wrenching situations no one wants to face.  And they can leave us scarred.

What to do if you experience traumatic events

“The first thing to do if you are exposed to a traumatic event is to talk about it,” says Dr. Margaret McKinnon, an HRI-supported scientist and trauma expert from McMaster University.

Dr. McKinnon serves as Homewood Research Chair in Mental Health and Trauma and is leading important research related to moral injury.

“Talk to your colleagues or close personal network. Failing to acknowledge a morally injurious event can make matters worse, so share your experiences and support one another. The next thing to do is to practice self-compassion and self-care as you move through these challenging times. Many virtual tools are now available to support our resilience and mental health.”

And finally, if you experience persistent and overwhelming feelings related to a traumatic experience that are severely disrupting your quality of life, talk to a mental health professional.

“Help is available, and protecting our mental wellbeing is of the utmost importance,” says McKinnon.

Mental health resources during COVID-19

If you are an Ontario healthcare worker, you can access free phone therapy sessions provided by licensed mental health workers who are volunteering their services during the COVID-19 pandemic.

For anyone experiencing mental health concerns, many online resources are available, including:

How to practice self-compassion and self-care

  • Accept your feelings without judgement. It is normal to feel negative emotions during uncertain times or after experiencing a traumatic event. Name your feelings and be gentle with yourself as you sit with them and process them.
  • Do your best to maintain healthy lifestyle habits. If you are able, maintain a regular sleep, exercise and meal schedule. Take breaks, communicate with your peers and family, and use mental health tools that work for you. A list of resources is available below.
  • Practice mindfulness techniques. A variety of mindfulness tools exist online. Apps such as Calm and Insight Timer provide guided recordings, breathing exercises, and other tools to stay grounded in the here and now.
  • Continue doing all you can. Follow public health recommendations to slow the spread of COVID-19. Stay informed via reputable news sources (but don’t be afraid to take a media break if you need one.) Remind yourself of the positive outcomes you contribute to each day.

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Mobilizing experts to address sexual misconduct in the military

In October 2019, 50 stakeholders from across Canada attended a workshop at the annual Canadian Institute for Military and Veteran Health Research Forum. The workshop focused on the psychological consequences of sexual misconduct during military service.

Researchers, policy makers, military members, veterans, and clinicians convened to explore the relation between exposure to sexual misconduct during military service and the onset of moral injury among female military members and veterans.

To mobilize action on these discussions, HRI hosted a symposium on December 3, 2019. Funded by the Government of Canada’s Defence Engagement Program, the symposium brought Canadian military and non-military experts together with a common goal of supporting the Canadian Armed Forces in addressing sexual misconduct.

The role of moral injury

Canada patch flags on soldiers arm

Work at HRI is exploring whether exposure to sexual misconduct in military environments is related to the onset of moral injury. For example, sexual misconduct may result in moral injury when an incident involves a perceived betrayal by those within a circle of trust or by an authority figure.

Similarly, a military member could be morally wounded by witnessing – but being unable to stop – a colleague from sexually harassing another military member.

The interplay between sexual misconduct and moral injury is complex and requires further investigation. What is known, however, is that military members affected by sexual misconduct in the workplace are at increased risk of post-traumatic stress disorder, anxiety, depression, and suicide.

Moving research, prevention, and intervention forward

During the December 3 symposium, discussions were diverse but focused on barriers, resources, and actionable items to affect change, including:

  • The rise of the internet and social media in skewing views of normal sexual behaviour and consent
  • Optimizing available resources for affected members, including the Sexual Misconduct Response Centre
  • Celebrating current training and education initiatives, including Operation Honour
  • Expanding education focused on emotional intelligence, boundary setting, assertiveness, bystander roles, and moral dilemmas
  • Understanding the needs of LGBTQ+ members, indigenous members, and members with disabilities
  • Improving screening tools to identify affected members or those at high risk of perpetrating sexual misconduct
  • Improving treatment and intervention approaches to help affected members
  • Vital research needs, including the need to explore where best to target resources, the link between sexual misconduct and moral injury, how to facilitate culture change among all levels and ranks, the value of peer support, and the need to expand research to include male, LGBTQ+ and non-binary members

Group of symposium attendees, December 3, 2019The symposium was attended by 18 representatives of leading universities, research centres, and treatment providers, as well as the Department of National Defence, Veteran’s Affairs Canada, Servicewomen’s Salute, and the Canadian Institute for Military and Veteran Health Research.

Dr. Margaret McKinnon, Homewood Research Chair in Mental Health and Trauma, is the lead investigator on this research. Key collaborators include:

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International study explores how AA contributes to recovery

Treatment of alcohol use disorder is multi-faceted and often includes participation in mutual-support groups, the oldest and largest of which is Alcoholics Anonymous (AA).

Although frequent AA meeting attendance is associated with greater abstinence from alcohol, there is little understanding of the specific mechanisms by which AA benefits people. In other words, we know that AA works, but we aren’t sure how.

Recent studies suggest that AA may prompt important behavioural changes by positively impacting impulsivity and social networks. New research from the Peter Boris Centre for Addictions Research will take a deeper dive into this theory. The study will be led by Dr. James MacKillop, Peter Boris Chair in Addictions and HRI Senior Scientist, and Dr. John Kelly, Elizabeth R. Spallin Professor of Psychiatry in Addiction Medicine at Harvard Medical School. Their team will examine impulsivity and social networks to see how these mechanisms drive recovery success in AA attendees.

The process

Researchers will follow people seeking treatment for alcohol use disorder in both inpatient and outpatient settings. The study will involve participants from multiple treatment programs based in Guelph and Hamilton, Ontario, and Boston, Massachusetts.

Participants will be assessed when they enter treatment, at 4-6 weeks into treatment, and at four more time points over a one-year period. Assessments will ask about alcohol use, personality traits, family and peer behaviour, and general personal and health information. Novel approaches will be employed to measure impulsive behaviour and analyze social networks, allowing researchers to determine how these mechanisms relate to abstinence and other markers of recovery.

Generating new knowledge to help recovery

This study will shed light on the psychological and social mechanisms of recovery and how AA activates these mechanisms. Researchers also hope to discover factors that could predict positive or negative experiences with AA. Clinicians and scientists may also use findings to identify therapeutic targets for people receiving treatment in an effort to boost recovery success.

Funding and collaboration

This study, entitled Investigating Impulsivity and Social Network Changes as Novel Mechanisms of Behavioural Change for Alcoholics Anonymous’ (AA) Positive Effects, is funded by the US National Institute of Alcohol Abuse and Alcoholism (NIAAA).

Collaborators on this project include:

  • John Kelly (Massachusetts General Hospital, Harvard Medical School)
  • Robert Stout (PIRE Decision Sciences Institute, Providence, RI USA)
  • Allan Clifton (Vassar College, New York, USA)

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Evidence 101: Q&A with an expert

Dr. David Streiner has attempted to retire three times, but this biostatistics expert is in high demand.

Dr. David Streiner headshot

Dr. David Streiner

Having trained as a clinical psychologist more than 50 years ago, Dr. Streiner is now Professor Emeritus in both the Department of Psychiatry and Behavioural Neurosciences and the Department of Clinical Epidemiology and Biostatistics at McMaster University, and a Professor in the Department of Psychiatry at the University of Toronto.

His research expertise is sought by scientists, faculty, residents, and students alike. A star behind the scenes, Dr. Streiner frequently consults with HRI scientists and trainees on everything from study design to research analysis.

In this question-and-answer feature, Dr. Streiner provides clarity about some of the most common questions we receive at HRI about evidence.

What does “evidence” mean in the context of healthcare?

Evidence is the available body of facts that healthcare providers can draw from to best treat patients. The most common method of obtaining healthcare evidence today is through research studies. Prior to the rise of scientific healthcare research, evidence was based primarily on clinical expertise and opinion.

What is “evidence-based practice” in healthcare?

The term “evidence-based practice” originated from Dr. David Sackett, an American-Canadian physician who defined the term as “…the conscientious, explicit, and judicious use of the current best evidence in making decisions about the care of patients.”

So when using an evidence-based approach, one would base healthcare decisions solely on evidence from scientific research.

How is “evidence-informed practice” different from “evidence-based practice”?

Early critics of evidence-based practice argued that its definition limited medicine to a “cookbook approach” that fails to consider each patient’s unique values and preferences, and downplays the clinician’s experience and knowledge of the patient. A new term began to circulate, which encompassed a more person-centred approach:  evidence-informed practice.

Over time, the concept of evidence-based practice has evolved to include not only scientific research but also clinical expertise and the patient perspective brought to light by proponents of evidence-informed practice. Today, we see both terms used interchangeably.

How do we create evidence in healthcare?

First of all, we need research. Without research, we have no evidence. But to do research, we also need participants. We know that research plays a central role in designing and evaluating new treatments, but we often forget that patients and families play a central role in the research itself.

When answering research questions, we use a variety of methodologies. For example, if we want to know about the prevalence of a medical condition in a population, a cross-sectional study would be appropriate. On the other hand, if we want to find out whether a proposed treatment would help people with a specific condition, a randomized controlled trial would be used. At the end of the day, the research methodology depends on the question being asked.

The following infographic outlines some of the most common research approaches used at HRI:

Infographic explaining several types of research studies



New findings released from study examining long-term recovery outcomes

HRI has released an infographic featuring recent findings from a study that aims to shed light on the process of recovery from mental illness and addiction.

The Recovery Journey Project is a multi-year, longitudinal study conducted and led by researchers at HRI. As an independent research organization, HRI works with treatment providers to collect data from former patients and clients for up to one year after treatment to better understand the progress patients make and challenges they face during recovery.

The primary goal of the project is to provide evidence that can guide and continually improve treatment approaches to help people achieve long-term recovery.

Since 2015, HRI has conducted research with patients who receive residential treatment for addictions at Homewood Health Centre, in Guelph, Ontario. Recent findings were published in an infographic and accompanying background report. The infographic shows changes in various indicators of recovery for patients who were admitted to the Addiction Medicine Service between April 2016 and March 2017 and whose progress was followed from admission to 12 months after completing treatment.

View the infographic

View the background report

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Investigating the experience of female military members and veterans exposed to inappropriate sexual behaviour

With support from the Government of Canada’s Defence Engagement Program, HRI has launched a collaborative effort to better understand the unique experience of servicewomen. Specifically, the project aims to explore the relationship between exposure to inappropriate sexual behaviour during military service and the onset of moral injury among female military members and veterans.

Moral injury refers to the psychological distress that individuals may experience when their personal moral beliefs have been betrayed – either by themselves or by someone else (e.g., an authority figure.)

“Inappropriate sexual behaviour has been linked to moral injury in other armed forces settings,” says Dr. Margaret McKinnon, Homewood Research Chair in Mental Health and Trauma, and lead investigator on the study.

“Unfortunately, the majority of studies to date have been conducted in U.S. settings, so the impact of this behaviour is unknown in the Canadian context.”

Experiences that lead to moral injury are strongly associated with the development of post-traumatic stress disorder, major depressive disorder, anxiety, and suicidal ideation. With a better understanding of how moral injury may factor into the experiences of servicewomen affected by inappropriate sexual behaviour, treatment providers can intervene more quickly and effectively.

“Another major goal of this initiative is to mobilize scholars, clinicians and policy makers who can work with us to address concerns related to moral injury within these populations,” says McKinnon.

Key collaborators on this project include:

Focus groups are now underway with female military members and veterans to discuss their experiences and the events that may trigger potential feelings associated with moral injury, such as shame and guilt.

Workshops are also being held with researchers, clinicians, and scientists to examine the psychological consequences of exposure to inappropriate sexual behaviour and the potential steps that can be taken to address these concerns in partnership with the military.

On October 23, 2019, the research team hosted an interactive workshop at the annual Canadian Institute for Military and Veteran Research (CIMVHR) Forum. Thought leaders from the government, academia, industry, health and philanthropic sectors were present to share ideas and insights on how to move research, prevention and intervention strategies forward.

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